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1,3,8-triaza- and 3,8-diaza-1-oxaspiro ?4,5! decane derivatives
Patent number: 5739336
Abstract: Heterocyclic compounds of Formula I: ##STR1## in which n is 2, 3, 4, 5 or 6; t is 1, 2, 3 or 4; u is 0 or 1 (provided that t is not 1 when u is 0); X is O or N(R.sup.4); Y and Z are independently C(O), C(S) or CH.sub.2 (provided that Y and Z are not both CH.sub.2); R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined in the specification; and their pharmaceutically acceptable salts and N-oxides, formulations containing them, their uses as therapeutic agents, and their synthesis.
Type: Grant
Filed: June 20, 1996
Date of Patent: April 14, 1998
Assignee: Syntex (U.S.A.) Inc.
Inventors: Klaus K. Weinhardt, Jacob Berger, David S. Carter, Lee A. Flippin
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Process for the preparation of inhibitors of macrophage migration inhibitory factor
Patent number: 7238809
Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
Type: Grant
Filed: May 2, 2006
Date of Patent: July 3, 2007
Assignee: Avanir Pharmaceuticals
Inventors: Federico C. A. Gaeta, Andrew Baird, Jerry Anchin, Wenbin Ying, Robert Florkiewicz, Jagadish Sircar, Sunil Kumar K. C.
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Process for the preparation of inhibitors of macrophage migration inhibitory factor
Patent number: 7230106
Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
Type: Grant
Filed: May 2, 2006
Date of Patent: June 12, 2007
Assignee: Avanir Pharmaceuticals
Inventors: Federico C. A. Gaeta, Andrew Baird, Jerry Anchin, Wenbin Ying, Robert Florkiewicz, Jagadish Sircar, Sunil Kumar K. C.
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Method for oxidizing hydrocarbons
Patent number: 6852893
Abstract: The invention relates to a method for oxidizing substrates such as hydrocarbons, waxes or soot. The method involves the use of a compound of formula (I) in which: R1 and R2 represent H, an aliphatic or aromatic alkoxy radical, carboxyl radical, alkoxycarbonyl radical or hydrocarbon radical, each having 1 to 20 hydrocarbon atoms, SO3H, NH2, OH, F, Cl, Br, I and/or NO2, whereby R1 and R2 designate identical or different radicals or R1 and R2 can be linked to one another via a covalent bonding; Q1 and Q2 represent C, CH, N, CR5, each being the same or different; X and Z represent C, S, CH2, each being the same or different; Y represents O and OH; k=0, 1, 2; l=0, 1, 2; m=1 to 3, and; R5 represents one of the meanings of R1. Said compound is used as a catalyst in the presence of a radical initiator, whereby the molar ratio of the catalyst to the hydrocarbon is less than 10 mol %. Peroxy compounds or azo compounds can be used as the radical initiator. Preferred substrates are aliphatic or aromatic hydrocarbons.
Type: Grant
Filed: March 22, 2001
Date of Patent: February 8, 2005
Assignee: Creavis Gesellschaft fuer Technologie and Innovation mbH
Inventors: Adolf Kühnle, Mark Duda, Carsten Jost, Guido Fries, Jochen Kirchhoff, Thomas Schiffer, Roger Arthur Sheldon, Sasidharan Manickam, Isabella W. C. E. Arends
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Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
Patent number: 7235565
Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
Type: Grant
Filed: May 2, 2006
Date of Patent: June 26, 2007
Assignee: Avanir Pharmaceuticals
Inventors: Federico C. A. Gaeta, Andrew Baird, Jerry Anchin, Wenbin Ying, Robert Florkiewicz, Jagadish Sircar, Sunil Kumar K.C.
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Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
Patent number: 7129236
Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
Type: Grant
Filed: May 2, 2006
Date of Patent: October 31, 2006
Assignee: Avanir Pharmaceuticals
Inventors: Federico C. A. Gaeta, Andrew Baird, Jerry Anchin, Wenbin Ying, Robert Florkiewicz, Jagadish Sircar, Sunil Kumar K.C.
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Method for screening an agent that modulates activity of macrophage migration inhibitory factor
Patent number: 7732146
Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
Type: Grant
Filed: July 15, 2005
Date of Patent: June 8, 2010
Assignee: Avanir Pharmaceuticals
Inventors: Federico C. A. Gaeta, Andrew Baird, Jerry Anchin, Wenbin Ying, Robert Florkiewicz, Jagadish Sircar, Sunil Kumar K.C.
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Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
Patent number: 7157469
Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
Type: Grant
Filed: May 2, 2006
Date of Patent: January 2, 2007
Assignee: Avanir Pharmaceuticals
Inventors: Federico C. A. Gaeta, Andrew Baird, Jerry Anchin, Wenbin Ying, Robert Florkiewicz, Jagadish Sircar, Sunil Kumar K. C.
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Method for screening an agent that modulates activity of macrophage migration inhibitory factor
Patent number: 7514225
Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
Type: Grant
Filed: July 15, 2005
Date of Patent: April 7, 2009
Assignee: Avanir Pharmaceuticals
Inventors: Federico C. A. Gaeta, Andrew Baird, Jerry Anchin, Wenbin Ying, Robert Florkiewicz, Jagadish Sircar, Sunil Kumar K. C.
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SILICATE BASE LUMINESCENT MATERIALS HAVING MULTIPLE EMISSION PEAKS, PROCESSES FOR PREPARING THE SAME AND LIGHT EMITTING DEVICES USING THE SAME
Publication number: 20100052513
Abstract: A silicate luminescent material excitable by an excitation light source having emissions in UV to blue light region, a process for producing the same, and a white light emitting device. The luminescent material has an emission spectrum with at least two peaks in a range of from 370 to 760 nm, and has a general chemical composition formula of aAO.bA?O.cSiO2:xEu.yLn.zM.?N, wherein A is selected from the group consisting of Sr, Ca, Ba, and combinations thereof; A? is selected from the group consisting of Mg, Zn, and combinations thereof; Ln is selected from the group consisting of Nd, Dy, Ho, Tm, La, Ce, Er, Pr, Bi, Sm, Sn, Y, Lu, Ga, Sb, Tb, Mn, Pb and combinations thereof; M is one or a combination of halogen ions; N is selected from the group consisting of Li+, Na+, K+, Ag+, and combinations thereof; and a, b, c, x, y, z, and ? are molar coefficients.
Type: Application
Filed: August 15, 2007
Publication date: March 4, 2010
Applicant: LUMING SCIENCE AND TECHNOLOGY GROUP CO., LTD.
Inventors: Wei Xia, Yi Xin, Daqiang Hu, Zhiguo Xiao
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Process for the photochemical dehydrogenation of alcohols with semiconductor powder suspensions
Patent number: 4655891
Abstract: A process for the photochemical dehydrogenation of alcohols comprises the steps of forming a suspension of semiconductor powder in the alcohol and photochemically activating the suspension in the presence of an oxidant with illumination having an energy at least equal to the band gap of the semiconductor powder. The process is one carried out at about ambient temperature and with gentle agitation. The semiconductor powder has the general formula A.sub.x B.sub.y C.sub.z where A is selected from Bi, Sn, Pt, Pd, Cu, Fe, W, V, Sb, Mo, Ru or Ag and mixtures thereof; B is Te, Sb, Ti, Cd, Mo, W or V and mixtures thereof; C is O or S; x equals 0.1 to 5; y equals 1 to 3; and z is a number necessary to satisfy the other elements, and is optionally metallized by an element selected from Pt, Pd, Cu or Ag.
Type: Grant
Filed: August 22, 1984
Date of Patent: April 7, 1987
Assignee: The Standard Oil Company
Inventors: Michael D. Ward, James F. Brazdil, Jr., Robert K. Grasselli
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Organic electroluminescent materials and devices
Patent number: 10457699
Abstract: A compound that has the structure according to Formula M(LA)x(LB)y(LC)z: wherein ligand LA is ligand LB is and ligand LC is and devices and formulations containing these compounds are disclosed. In Formula M(LA)x(LB)y(LC)z: M is a metal having an atomic number greater than 40; x is 1 or 2; x+y+z is the oxidation state of the metal M; X1-X4 and A1-A8 are C or N; at least one of A1-A8 is N; X is O, S, or Se; two adjacent RB form a six-member aromatic ring E fused to ring B; wherein ring E can be substituted by RE; each RA-RE and R1-R4 is independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof.
Type: Grant
Filed: May 2, 2014
Date of Patent: October 29, 2019
Assignee: Universal Display Corporation
Inventors: Pierre-Luc T. Boudreault, Vadim Adamovich, Hitoshi Yamamoto, Harvey Wendt, Chuanjun Xia
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Silicate base luminescent materials having multiple emission peaks, processes for preparing the same and light emitting devices using the same
Patent number: 8154191
Abstract: A silicate luminescent material excitable by an excitation light source having emissions in UV to blue light region, a process for producing the same, and a white light emitting device. The luminescent material has an emission spectrum with at least two peaks in a range of from 370 to 760 nm, and has a general chemical composition formula of aAO.bA?O.cSiO2:xEu.yLn.zM.?N, wherein A is selected from the group consisting of Sr, Ca, Ba, and combinations thereof; A? is selected from the group consisting of Mg, Zn, and combinations thereof; Ln is selected from the group consisting of Nd, Dy, Ho, Tm, La, Ce, Er, Pr, Bi, Sm, Sn, Y, Lu, Ga, Sb, Tb, Mn, Pb and combinations thereof; M is one or a combination of halogen ions; N is selected from the group consisting of Li+, Na+, K+, Ag+, and combinations thereof; and a, b, c, x, y, z, and ? are molar coefficients.
Type: Grant
Filed: August 15, 2007
Date of Patent: April 10, 2012
Assignee: Luming Science And Technology Group Co., Ltd.
Inventors: Wei Xia, Yi Xin, Daqiang Hu, Zhiguo Xiao
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SMALL MOLECULE INHIBITORS OF THE NUCLEAR TRANSLOCATION OF ANDROGEN RECEPTOR FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER
Publication number: 20160257657
Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(?O), —S(?O)(?O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl alkadienyl, substituted alkadienyl, alkatrienyl, substituted alkatrienyl; X is —C(?O)—, —S(?O)(?O)—, or —N(H)C(?O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.
Type: Application
Filed: March 24, 2016
Publication date: September 8, 2016
Inventors: Peter Wipf, James K. Johnson, Erin M. Skoda, Joel B. Nelson, Zhou Wang
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Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
Patent number: 7105519
Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
Type: Grant
Filed: May 24, 2002
Date of Patent: September 12, 2006
Assignee: Avanir Pharmaceuticals
Inventors: Federico C. A. Gaeta, Andrew Baird, Jerry Anchin, Wenbin Ying, Robert Florkiewicz, Jagadish Sircar, Sunil Mumar K. C.
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SMALL MOLECULE INHIBITORS OF THE NUCLEAR TRANSLOCATION OF ANDROGEN RECEPTOR FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER
Publication number: 20180237403
Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(?O), —S(?O)(?O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl alkadienyl, substituted alkadienyl, alkatrienyl, substituted alkatrienyl; X is —C(?O)—, —S(?O)(?O)—, or —N(H)C(?O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.
Type: Application
Filed: April 24, 2018
Publication date: August 23, 2018
Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
Inventors: Peter Wipf, James K. Johnson, Erin M. Skoda, Joel B. Nelson, Zhou Wang
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Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
Patent number: 10544110
Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(?O), —S(?O)(?O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl alkadienyl, substituted alkadienyl, alkatrienyl, substituted alkatrienyl; X is —C(?O)—, —S(?O)(?O)—, or —N(H)C(?O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.
Type: Grant
Filed: April 24, 2018
Date of Patent: January 28, 2020
Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
Inventors: Peter Wipf, James K. Johnson, Erin M. Skoda, Joel B. Nelson, Zhou Wang
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Novel tertiary alcohol compounds having alicyclic structure
Publication number: 20040254394
Abstract: Tertiary alcohol compounds of formula (1) are novel wherein R1 and R2 are C1-10 alkyl groups which may have halogen substituents, or R1 and R2 may form an aliphatic hydrocarbon ring, Y and Z are a single bond or a divalent C1-10 organic group, and k=0 or 1. Using the tertiary alcohol compounds as a monomer, polymers are obtained. A resist composition comprising the polymer as a base resin is sensitive to high-energy radiation and has excellent sensitivity, resolution, etching resistance and substrate adhesion.
Type: Application
Filed: July 15, 2004
Publication date: December 16, 2004
Inventors: Koji Hasegawa, Takeru Watanabe, Takeshi Kinsho
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Five-axis machining apparatus
Patent number: 9700975
Abstract: Disclosed is a five axis machining apparatus. The five axis machining apparatus comprises a base member, a support member, a stationary base, a first moving plate, a second moving plate, a third moving plate, a fourth moving frame, a fifth moving frame and a controller (not shown). The five axis machining apparatus is designed to hold together A, C and X axes thereby resulting in a reduced size without compromising on rigidity that is required for processing metallic job components. The five axis machining apparatus allows independent as well as simultaneous control of X, Y, Z, A and C axes.
Type: Grant
Filed: December 30, 2014
Date of Patent: July 11, 2017
Inventor: Nitin Narayan Kelkar
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Cephalosporin antibiotics
Patent number: 5571804
Abstract: Cephalosporin compounds of formula (I): ##STR1## wherein: R.sup.1 is a hydrogen or an amino protecting group;R.sup.2 and R.sup.3 are, independently, a hydrogen or a hydroxy protecting group, or form together a cyclic diol protecting group;R.sup.4 and R.sup.5 are, independently, a hydrogen or a carboxyl protecting group;X and Y are a nitrogen and a carbon atom, respectively, or a carbon and a nitrogen atom, respectively;R.sup.6 and R.sup.7 are, independently, a hydrogen or an amino, substituted amino, hydroxy, alkoxy, C.sub.1-4 alkyl, carboxyl or alkoxy carbonyl group, or jointly form a C.sub.3-7 cycloalkyl group together with the carbon to which they are attached, when X and Y are a nitrogen and a carbon, respectively, or R.sup.7 is a hydrogen or an amino group when X and Y are a carbon and a nitrogen, respectively; andQ is .dbd.CH-- or .dbd.
Type: Grant
Filed: September 9, 1994
Date of Patent: November 5, 1996
Assignee: Lucky Limited
Inventors: Chan S. Bang, Jae H. Yeo, Young M. Woo, Jong C. Lim, Deog H. Yang, Se H. Kim, Jae H. Jeon, Mi K. Seo, Sam S. Kim, Tae H. Lee, Yong Z. Kim, Hun S. Oh
